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ea0073aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Inhibition of ATG3 ameliorates liver steatosis by increasing SIRT1 in an autophagic-independent action

Novoa Eva , Nátalia da Silva Lima , Marcos Férnandez Fondevila , Buque Xabier , María Jesús González Rellán , Uxía Fernández Paz , María García Vence , María del Pilar Chantada Vázquez , Bravo Susana , Patricia Marañon , Escudero Adriana , Leiva Magdalena , Fidalgo Miguel , Gomes Pedro , Claret Marc , Sabio Guadalupe , Rey Marta Varela , Delgado Teresa , Miguel López , Carlos Diéguez , María Martínez Chantar , Carmelo García Monzon , Agueda González Rodríguez , Aspichueta Patricia , Rubén Nogueiras Pozo

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...

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Endocrine Abstracts

Inhibition of ATG3 ameliorates liver steatosis by increasing SIRT1 in an autophagic-independent action

BiosciAbstracts